Across TCGA cell cohorts, MYO5A mutation is significantly associated with the RNA expression of many other genes, with 625 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO5A-associated genes across cancer lineages are RASGEF1C, RAB19, and CABP5. Each is linked with MYO5A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO5A-to-partner and partner-to-MYO5A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO5A→partner) and Y-score (partner→MYO5A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RASGEF1C →	+0.156	+1.514	.003	.008	3	2
LARGE_INTESTINE	RAB19 →	+0.750	+3.459	<.001	<.001	3	2
BLOOD_Lymphoma	CABP5 →	+0.008	+3.452	<.001	.004	3	1
BLOOD_Lymphoma	NR2E1 →	+0.031	+4.428	<.001	<.001	3	1
BLOOD_Lymphoma	ALLC →	+1.029	+3.310	<.001	.009	3	1
BLOOD_Lymphoma	MUC7 →	+0.015	+3.021	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 625 associations by consensus.

Exploration

MYO5A survival (RNA) · tumor vs normal (RNA) · all MYO5A data types