MYO3B

Across TCGA patient cohorts, MYO3B mutation is significantly associated with the RNA expression of many other genes, with 5,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO3B-associated genes across cancer lineages are RNU6-540P, RNU6-1285P, and HSPA4L. Each is linked with MYO3B in more than 4 cancer types. Because this analysis shows association rather than direction, both MYO3B-to-partner and partner-to-MYO3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-540P grouped by MYO3B-low versus MYO3B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO3B→partner) and Y-score (partner→MYO3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-540P →	+0.158	+1.158	.002	.008	3	5
LIHC	RNU6-1285P →	+0.634	+4.207	<.001	.009	3	4
UCEC	HSPA4L →	+0.655	+2.403	<.001	<.001	3	4
UCEC	NIPA1 →	+0.732	+1.649	<.001	<.001	3	4
UCEC	GEMIN2 →	+0.303	+1.470	.008	<.001	3	4
LUAD	PEX13 →	+0.351	+3.744	.004	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,445 associations by consensus.

RNU6-540P by MYO3B expression — SKCM

Explore this box plot interactively →