MYO3B

Across TCGA patient cohorts, MYO3B mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO3B-associated genes across cancer lineages are 4E-BP1, PCNA, and Acetyl-a-Tubulin-Lys40. Each is linked with MYO3B in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO3B-to-partner and partner-to-MYO3B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYO3B-low versus MYO3B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO3B→partner) and Y-score (partner→MYO3B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.342	+3.087	<.001	<.001	3	4
UCEC	PCNA →	+0.228	+1.807	<.001	<.001	3	4
SKCM	Acetyl-a-Tubulin-Lys40 →	+0.453	+1.440	.005	.020	3	3
SKCM	Caveolin-1 →	-0.478	-1.584	.009	.030	3	3
UCEC	eIF4E →	+0.189	+2.321	.002	<.001	3	3
UCEC	JNK_pT183_Y185 →	-0.197	-2.459	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

4E-BP1 by MYO3B expression — UCEC

Explore this box plot interactively →