MYO3A

Across TCGA patient cohorts, MYO3A mutation is significantly associated with the RNA expression of many other genes, with 5,825 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO3A-associated genes across cancer lineages are CEP78, OTX1, and NARS1. Each is linked with MYO3A in more than 5 cancer types. Because this analysis shows association rather than direction, both MYO3A-to-partner and partner-to-MYO3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEP78 grouped by MYO3A-low versus MYO3A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO3A→partner) and Y-score (partner→MYO3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CEP78 →	+0.472	+1.765	<.001	<.001	3	6
BLCA	OTX1 →	+0.647	+3.336	.002	.004	3	5
COAD	NARS1 →	+0.337	+1.878	.001	.004	3	5
LUAD	SKA1 →	+0.926	+2.620	<.001	<.001	3	5
UCEC	HELLS →	+0.424	+1.296	<.001	.001	3	5
LUAD	PSMC3IP →	+0.616	+2.632	<.001	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,825 associations by consensus.

CEP78 by MYO3A expression — UCEC

Explore this box plot interactively →