MYO3A

Across TCGA cell cohorts, MYO3A mutation is significantly associated with the RNA expression of many other genes, with 347 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO3A-associated genes across cancer lineages are SLCO1B7, EEF1A2, and NDUFC1. Each is linked with MYO3A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO3A-to-partner and partner-to-MYO3A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1B7 grouped by MYO3A-low versus MYO3A-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO3A→partner) and Y-score (partner→MYO3A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLCO1B7 →	+0.221	+3.220	<.001	.002	3	2
LARGE_INTESTINE	EEF1A2 →	-2.146	-2.278	.003	.001	3	2
LARGE_INTESTINE	NDUFC1 →	+0.621	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	TTC19 →	+0.475	+1.850	.009	.006	3	2
LARGE_INTESTINE	KDSR →	+0.600	+2.364	.004	<.001	3	2
LARGE_INTESTINE	SOD1 →	+0.567	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 347 associations by consensus.

SLCO1B7 by MYO3A expression — LUNG_SCLC

Explore this box plot interactively →