MYO1G

Across TCGA patient cohorts, MYO1G mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MYO1G-associated genes across cancer lineages are Cyclin-B1, INPP4B, and TFRC. Each is linked with MYO1G in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO1G-to-partner and partner-to-MYO1G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MYO1G-low versus MYO1G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1G→partner) and Y-score (partner→MYO1G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.599	+3.321	.003	.010	3	3
COAD	INPP4B →	-0.611	-3.798	<.001	<.001	3	2
UCEC	TFRC →	+0.391	+1.847	.045	.008	3	2
UCEC	4E-BP1 →	+0.373	+2.252	<.001	.005	2	3
COAD	PAI-1 →	+0.591	+2.008	.013	.018	3	2
COAD	PDCD4 →	-0.392	-2.691	.021	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by MYO1G expression — UCEC

Explore this box plot interactively →