MYO1F

Across TCGA patient cohorts, MYO1F mutation is significantly associated with the total protein of many other genes, with 75 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1F-associated genes across cancer lineages are FoxM1, Cyclin-B1, and Src_pY527. Each is linked with MYO1F in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO1F-to-partner and partner-to-MYO1F results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MYO1F-low versus MYO1F-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1F→partner) and Y-score (partner→MYO1F) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.199	+1.415	.013	.010	3	4
UCEC	Cyclin-B1 →	+0.554	+2.321	.001	.005	3	4
STAD	Src_pY527 →	-0.695	-3.906	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.281	+2.222	<.001	.009	3	3
COAD	Di-Ras3 →	-0.188	-2.000	.007	.029	3	3
UCEC	ASNS →	+0.387	+1.514	<.001	.014	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 75 associations by consensus.

FoxM1 by MYO1F expression — UCEC

Explore this box plot interactively →