MYO1E

Across TCGA patient cohorts, MYO1E mutation is significantly associated with the RNA expression of many other genes, with 4,117 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1E-associated genes across cancer lineages are H2AC14, LEO1, and SEC11C. Each is linked with MYO1E in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO1E-to-partner and partner-to-MYO1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H2AC14 grouped by MYO1E-low versus MYO1E-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1E→partner) and Y-score (partner→MYO1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	H2AC14 →	+1.422	+2.820	<.001	.001	3	3
UCEC	LEO1 →	+0.373	+2.102	.001	<.001	3	3
UCEC	SEC11C →	+0.425	+2.606	.002	<.001	3	3
UCEC	CLPX →	+0.331	+1.852	.004	<.001	3	3
UCEC	GTSE1 →	+0.668	+1.894	<.001	<.001	3	3
COAD	SHMT2 →	+0.598	+2.807	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,117 associations by consensus.

H2AC14 by MYO1E expression — COAD

Explore this box plot interactively →