MYO1E

Across TCGA patient cohorts, MYO1E mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1E-associated genes across cancer lineages are PDCD4, ATM, and INPP4B. Each is linked with MYO1E in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO1E-to-partner and partner-to-MYO1E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by MYO1E-low versus MYO1E-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1E→partner) and Y-score (partner→MYO1E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.389	-1.584	.005	.032	3	4
UCEC	ATM →	-0.444	-3.893	.001	<.001	3	3
COAD	INPP4B →	-0.487	-3.321	.001	.009	3	2
UCEC	MEK1 →	+0.338	+2.000	.001	<.001	3	2
COAD	PCNA →	+0.262	+1.882	.011	.031	3	2
UCEC	Rad50 →	-0.151	-1.184	.036	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

PDCD4 by MYO1E expression — UCEC

Explore this box plot interactively →