MYO1A

Across TCGA patient cohorts, MYO1A mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO1A-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and STAT3_pY705. Each is linked with MYO1A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO1A-to-partner and partner-to-MYO1A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by MYO1A-low versus MYO1A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO1A→partner) and Y-score (partner→MYO1A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.357	+2.050	<.001	<.001	2	4
UCEC	Cyclin-B1 →	+0.711	+2.050	<.001	<.001	3	3
BLCA	STAT3_pY705 →	-0.324	-3.000	.020	.036	3	2
BLCA	TFRC →	+0.526	+3.000	.040	.036	1	4
UCEC	EGFR_pY1068 →	-0.217	-1.584	.003	.002	3	2
UCEC	GAPDH →	+0.373	+1.378	.019	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1 by MYO1A expression — UCEC

Explore this box plot interactively →