MYO19

Across TCGA cell cohorts, MYO19 mutation is significantly associated with the RNA expression of many other genes, with 317 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO19-associated genes across cancer lineages are PRAMEF20, LRRC72, and KRTAP10-3. Each is linked with MYO19 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYO19-to-partner and partner-to-MYO19 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRAMEF20 grouped by MYO19-low versus MYO19-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO19→partner) and Y-score (partner→MYO19) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	PRAMEF20 →	+0.367	+4.269	<.001	.005	3	2
LUNG_SCLC	LRRC72 →	+0.056	+5.169	<.001	<.001	3	2
BLOOD_Leukemia	KRTAP10-3 →	+0.058	+5.060	<.001	.001	3	2
BONE	MTNR1B →	+0.030	+4.000	.002	.008	3	1
LUNG_NSCLC_LUSC	OR8B8 →	+0.036	+3.584	<.001	.003	3	1
BLOOD_Lymphoma	CALHM4 →	+0.221	+3.180	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 317 associations by consensus.

PRAMEF20 by MYO19 expression — LUNG_SCLC

Explore this box plot interactively →