MYO18B

Across TCGA patient cohorts, MYO18B mutation is significantly associated with the total protein of many other genes, with 97 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO18B-associated genes across cancer lineages are MIG-6, PKC-b-II_pS660, and JNK_pT183_Y185. Each is linked with MYO18B in more than 5 cancer types. Because this analysis shows association rather than direction, both MYO18B-to-partner and partner-to-MYO18B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIG-6 grouped by MYO18B-low versus MYO18B-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO18B→partner) and Y-score (partner→MYO18B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIG-6 →	+0.064	+2.115	.032	.015	3	6
SKCM	PKC-b-II_pS660 →	-0.132	-0.906	.044	.031	3	5
STAD	JNK_pT183_Y185 →	-0.096	-2.979	.028	.033	3	4
STAD	MYH11 →	-1.586	-2.459	.005	.018	3	4
STAD	Caspase-7-cleavedD198 →	+0.807	+3.169	.004	.017	3	4
STAD	Caveolin-1 →	-1.029	-3.999	<.001	<.001	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 97 associations by consensus.

MIG-6 by MYO18B expression — COAD

Explore this box plot interactively →