Across TCGA patient cohorts, MYO18A mutation is significantly associated with the RNA expression of many other genes, with 7,928 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO18A-associated genes across cancer lineages are GLRX5, FEN1, and SYT7. Each is linked with MYO18A in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO18A-to-partner and partner-to-MYO18A results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO18A→partner) and Y-score (partner→MYO18A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX5 →	+0.283	+2.074	<.001	<.001	3	4
UCEC	FEN1 →	+0.514	+1.302	<.001	<.001	3	4
COAD	SYT7 →	-1.565	-2.510	<.001	<.001	3	3
BLCA	FBXL5 →	+0.499	+2.707	.003	.004	3	3
UCEC	AATF →	+0.272	+1.652	.002	<.001	3	3
UCEC	JOSD1 →	+0.365	+1.652	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,928 associations by consensus.

Exploration

MYO18A survival (RNA) · tumor vs normal (RNA) · all MYO18A data types