MYO16

Across TCGA patient cohorts, MYO16 mutation is significantly associated with the total protein of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO16-associated genes across cancer lineages are ASNS, Mre11, and PCNA. Each is linked with MYO16 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYO16-to-partner and partner-to-MYO16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MYO16-low versus MYO16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO16→partner) and Y-score (partner→MYO16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.277	+1.378	.002	.006	3	4
HNSC	Mre11 →	-0.146	-3.000	.040	.031	3	3
UCEC	PCNA →	+0.206	+1.584	<.001	<.001	3	3
UCEC	S6_pS240_S244 →	+0.314	+1.584	.002	<.001	3	3
UCEC	VHL →	-0.544	-1.157	.001	.011	3	3
UCEC	ATM →	-0.435	-2.124	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

ASNS by MYO16 expression — UCEC

Explore this box plot interactively →