MYO16

Across TCGA cell cohorts, MYO16 mutation is significantly associated with the RNA expression of many other genes, with 679 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYO16-associated genes across cancer lineages are TTC19, LYG1, and HSD17B6. Each is linked with MYO16 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYO16-to-partner and partner-to-MYO16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TTC19 grouped by MYO16-low versus MYO16-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO16→partner) and Y-score (partner→MYO16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTC19 →	+0.639	+2.700	<.001	<.001	3	3
LARGE_INTESTINE	LYG1 →	+0.800	+1.628	<.001	.007	3	3
BLOOD_Leukemia	HSD17B6 →	+0.679	+3.228	.002	.004	3	3
BLOOD_Leukemia	GML →	+0.053	+2.205	<.001	.001	3	2
BLOOD_Leukemia	CSNKA2IP →	+0.056	+2.384	<.001	.001	3	2
LUNG_SCLC	C17orf98 →	+0.078	+2.635	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 679 associations by consensus.

TTC19 by MYO16 expression — LARGE_INTESTINE

Explore this box plot interactively →