MYO10

Across TCGA patient cohorts, MYO10 mutation is significantly associated with the total protein of many other genes, with 79 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYO10-associated genes across cancer lineages are Cyclin-E2, PCNA, and ATM. Each is linked with MYO10 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYO10-to-partner and partner-to-MYO10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-E2 grouped by MYO10-low versus MYO10-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYO10→partner) and Y-score (partner→MYO10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Cyclin-E2 →	+0.321	+3.610	<.001	.001	3	4
COAD	PCNA →	+0.274	+2.123	.004	.010	3	4
UCEC	ATM →	-0.522	-1.621	<.001	<.001	3	4
COAD	Caspase-7-cleavedD198 →	+1.294	+2.815	<.001	.001	3	4
BRCA	Heregulin →	+0.225	+3.348	.006	.005	3	3
BRCA	Chk1_pS345 →	+0.183	+3.013	.025	.019	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 79 associations by consensus.

Cyclin-E2 by MYO10 expression — COAD

Explore this box plot interactively →