MYNN

Across TCGA patient cohorts, MYNN mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYNN-associated genes across cancer lineages are GAPDH, p62 Lck ligand, and VEGFR2. Each is linked with MYNN in more than 1 cancer types. Because this analysis shows association rather than direction, both MYNN-to-partner and partner-to-MYNN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MYNN-low versus MYNN-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYNN→partner) and Y-score (partner→MYNN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.596	+2.000	.004	.010	3	2
UCEC	p62 Lck ligand →	+0.312	+2.009	.014	.017	3	2
UCEC	VEGFR2 →	+0.266	+1.598	.022	.022	3	2
UCEC	EGFR_pY1068 →	-0.331	-3.807	<.001	<.001	3	1
UCEC	eIF4E →	+0.192	+3.183	.020	.009	3	1
UCEC	ER-alpha →	-0.637	-2.446	.048	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

GAPDH by MYNN expression — UCEC

Explore this box plot interactively →