MYLK4

Across TCGA patient cohorts, MYLK4 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLK4-associated genes across cancer lineages are Notch1, FOXO3a_pS318_S321, and Ku80. Each is linked with MYLK4 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYLK4-to-partner and partner-to-MYLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MYLK4-low versus MYLK4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK4→partner) and Y-score (partner→MYLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.159	+3.183	.006	.009	3	3
SKCM	FOXO3a_pS318_S321 →	+0.258	+3.017	<.001	.019	3	2
UCEC	Ku80 →	+0.246	+2.335	.011	.003	3	2
UCEC	PCNA →	+0.252	+2.321	.004	.006	3	2
UCEC	XBP1 →	-0.212	-2.446	<.001	.018	3	2
SKCM	Bad_pS112 →	+0.308	+2.820	.003	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by MYLK4 expression — UCEC

Explore this box plot interactively →