MYLK4

Across TCGA cell cohorts, MYLK4 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. KIDNEY shows the largest number of these associations.

The most reproducible MYLK4-associated genes across cancer lineages are NPVF, GLYATL3, and KLF18. Each is linked with MYLK4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYLK4-to-partner and partner-to-MYLK4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NPVF grouped by MYLK4-low versus MYLK4-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK4→partner) and Y-score (partner→MYLK4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	NPVF →	+0.020	+5.000	<.001	.005	3	1
KIDNEY	GLYATL3 →	+0.043	+5.000	<.001	.005	3	1
KIDNEY	KLF18 →	+0.006	+5.000	<.001	.005	3	1
KIDNEY	RDH8 →	+0.063	+5.000	<.001	.005	3	1
CNS	DPRX →	+0.064	+5.321	<.001	.005	3	1
CNS	LEUTX →	+0.226	+5.321	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

NPVF by MYLK4 expression — KIDNEY

Explore this box plot interactively →