MYLK2

Across TCGA patient cohorts, MYLK2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,258 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible MYLK2-associated genes across cancer lineages are IER3, FOXQ1, and ZBTB16. Each is linked with MYLK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYLK2-to-partner and partner-to-MYLK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MYLK2 versus IER3 in BRCA, with a Pearson correlation of -0.34.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK2→partner) and Y-score (partner→MYLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IER3 →	-1.495	-1.317	.001	.007	3	2
OV	FOXQ1 →	-1.318	-0.704	.001	.009	3	2
HNSC	ZBTB16 →	+0.898	+0.960	.005	<.001	3	2
HNSC	APOBEC2 →	+1.114	+1.081	<.001	<.001	3	2
HNSC	MYBPH →	+2.496	+1.139	<.001	<.001	3	2
HNSC	AOX1 →	+1.306	+1.111	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,258 associations by consensus.

MYLK2 vs IER3 — BRCA

Explore this scatter interactively →