MYLK2

Across TCGA cell cohorts, MYLK2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,130 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYLK2-associated GO terms across cancer lineages are Spindle organization, Microtubule cytoskeleton organization involved in mitosis, and Mitotic spindle organization. Each is linked with MYLK2 in more than 17 cancer types. Because this analysis shows association rather than direction, both MYLK2-to-partner and partner-to-MYLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Spindle organization grouped by MYLK2-low versus MYLK2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK2→partner) and Y-score (partner→MYLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Spindle organization →	+0.088	+0.326	.002	<.001	3	18
OESOPHAGUS	Microtubule cytoskeleton organization involved in mitosis →	+0.108	+0.268	<.001	<.001	3	18
OESOPHAGUS	Mitotic spindle organization →	+0.112	+0.271	<.001	<.001	3	16
OESOPHAGUS	Sister chromatid segregation →	+0.134	+0.271	<.001	.001	3	16
OESOPHAGUS	Mitotic nuclear division →	+0.134	+0.306	<.001	.001	3	16
SKIN	Negative regulation of cell cycle phase transition →	+0.056	+0.265	<.001	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,130 associations by consensus.

Spindle organization by MYLK2 expression — OESOPHAGUS

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