MYLK2

Across TCGA cell cohorts, MYLK2 mutation is significantly associated with the RNA expression of many other genes, with 54 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MYLK2-associated genes across cancer lineages are STH, CST9, and GSG1L2. Each is linked with MYLK2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYLK2-to-partner and partner-to-MYLK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STH grouped by MYLK2-low versus MYLK2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK2→partner) and Y-score (partner→MYLK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	STH →	+0.185	+3.095	.006	.003	3	3
OVARY	CST9 →	+0.004	+4.222	<.001	.006	3	2
BLOOD_Leukemia	GSG1L2 →	+0.043	+4.969	<.001	.003	3	2
URINARY_TRACT	OTOR →	+0.030	+5.087	<.001	.004	3	1
OESOPHAGUS	SPATA31E1 →	+0.166	+4.906	<.001	.006	3	1
CNS	BTNL2 →	+0.034	+4.169	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

STH by MYLK2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →