MYLK

Across TCGA patient cohorts, MYLK mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYLK-associated genes across cancer lineages are GAPDH, eEF2, and N-Cadherin. Each is linked with MYLK in more than 4 cancer types. Because this analysis shows association rather than direction, both MYLK-to-partner and partner-to-MYLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by MYLK-low versus MYLK-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK→partner) and Y-score (partner→MYLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GAPDH →	+0.711	+3.169	.009	.020	3	5
UCEC	eEF2 →	+0.345	+2.807	<.001	<.001	3	4
UCEC	N-Cadherin →	+0.150	+2.137	.005	<.001	3	4
UCEC	ASNS →	+0.252	+1.000	.006	.016	3	4
UCEC	Bid →	+0.062	+1.222	.042	.029	3	4
LUAD	NF2 →	+0.222	+2.321	.038	.035	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

GAPDH by MYLK expression — BRCA

Explore this box plot interactively →