MYLK

Across TCGA cell cohorts, MYLK mutation is significantly associated with the RNA expression of many other genes, with 1,899 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYLK-associated genes across cancer lineages are CTSS, TAS2R42, and RABGGTB. Each is linked with MYLK in more than 3 cancer types. Because this analysis shows association rather than direction, both MYLK-to-partner and partner-to-MYLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CTSS grouped by MYLK-low versus MYLK-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK→partner) and Y-score (partner→MYLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CTSS →	-2.043	-3.459	<.001	<.001	3	4
BLOOD_Lymphoma	TAS2R42 →	+0.074	+3.740	<.001	.001	3	3
LARGE_INTESTINE	RABGGTB →	+0.780	+2.043	<.001	.001	3	3
LARGE_INTESTINE	BBS7 →	+0.749	+3.212	<.001	<.001	2	4
LARGE_INTESTINE	PRR14L →	+0.684	+2.043	<.001	.001	3	3
LARGE_INTESTINE	GAS2L1 →	+0.691	+3.459	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,899 associations by consensus.

CTSS by MYLK expression — LARGE_INTESTINE

Explore this box plot interactively →