MYLK

Across TCGA cell cohorts, MYLK mutation is significantly associated with the mutation status of many other genes, with 6,519 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYLK-associated genes across cancer lineages are MTOR, ANK3, and ADGRV1. Each is linked with MYLK in more than 5 cancer types. Because this analysis shows association rather than direction, both MYLK-to-partner and partner-to-MYLK results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTOR grouped by MYLK-low versus MYLK-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYLK→partner) and Y-score (partner→MYLK) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MTOR →	+3.722	+4.022	.003	.003	1	6
SOFT_TISSUE	ANK3 →	+5.307	+4.651	<.001	<.001	1	6
SOFT_TISSUE	ADGRV1 →	+3.137	+4.608	.001	.001	1	6
LUNG_NSCLC_LUAD	TNKS1BP1 →	+4.334	+2.924	.006	.006	1	6
CNS	LAMA2 →	+3.291	+3.785	<.001	<.001	1	6
STOMACH	RIMS1 →	+4.209	+3.000	.002	.002	1	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,519 associations by consensus.

MTOR by MYLK expression — SOFT_TISSUE

Explore this box plot interactively →