Across TCGA patient cohorts, MYL6B mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL6B-associated genes across cancer lineages are MEK1_p_S217_S221, NDRG1_pT346, and p62 Lck ligand. Each is linked with MYL6B in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL6B-to-partner and partner-to-MYL6B results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL6B→partner) and Y-score (partner→MYL6B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1_p_S217_S221 →	-0.358	-3.000	.012	.036	3	1
UCEC	NDRG1_pT346 →	-0.536	-3.321	.036	.010	3	1
UCEC	p62 Lck ligand →	+0.360	+3.009	.035	.019	3	1
UCEC	Paxillin →	+0.330	+2.817	.015	.036	3	1
UCEC	Src_pY416 →	-0.310	-3.169	.014	.019	3	1
UCEC	VEGFR2 →	+0.456	+3.009	.003	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

MYL6B survival (RNA) · tumor vs normal (RNA) · all MYL6B data types