MYL6

Across TCGA patient cohorts, MYL6 mutation is significantly associated with the RNA expression of many other genes, with 793 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL6-associated genes across cancer lineages are RNU6-258P, HNRNPH1P2, and RPL21P24. Each is linked with MYL6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL6-to-partner and partner-to-MYL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-258P grouped by MYL6-low versus MYL6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL6→partner) and Y-score (partner→MYL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RNU6-258P →	+0.310	+5.810	<.001	<.001	3	2
SKCM	HNRNPH1P2 →	+0.039	+3.490	<.001	.008	3	2
SKCM	RPL21P24 →	+0.082	+3.717	<.001	.005	3	2
CESC	ANKRD49P3 →	+0.064	+5.103	<.001	.008	3	2
BRCA	LINC02143 →	+0.318	+5.230	<.001	.007	3	2
LUAD	LINC01868 →	+0.099	+5.631	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 793 associations by consensus.

RNU6-258P by MYL6 expression — SKCM

Explore this box plot interactively →