Across TCGA patient cohorts, MYL5 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL5-associated genes across cancer lineages are SNORD114-12, RNU6-22P, and RN7SKP145. Each is linked with MYL5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL5-to-partner and partner-to-MYL5 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL5→partner) and Y-score (partner→MYL5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SNORD114-12 →	+0.394	+4.069	<.001	.008	3	2
UCEC	RNU6-22P →	+0.405	+3.029	<.001	.005	3	2
LUAD	RN7SKP145 →	+0.099	+7.930	<.001	.008	3	1
LUAD	RNU6-1097P →	+0.253	+7.930	<.001	.008	3	1
LUAD	IGLJ4 →	+0.722	+7.930	<.001	.008	3	1
CESC	RN7SL62P →	+0.155	+5.812	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

Exploration

MYL5 survival (RNA) · tumor vs normal (RNA) · all MYL5 data types