Across TCGA patient cohorts, MYL4 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL4-associated genes across cancer lineages are EGFR_pY1068, ERK2, and Lck. Each is linked with MYL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL4-to-partner and partner-to-MYL4 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL4→partner) and Y-score (partner→MYL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.334	-3.000	.015	.036	3	1
UCEC	ERK2 →	+0.298	+3.169	.004	.020	3	1
UCEC	Lck →	+0.335	+3.169	.002	.020	3	1
UCEC	NF2 →	+0.312	+3.169	.008	.020	3	1
UCEC	Caspase-7-cleavedD198 →	+1.100	+2.827	<.001	.035	3	1
UCEC	Bax →	+0.384	+2.817	.003	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

MYL4 survival (RNA) · tumor vs normal (RNA) · all MYL4 data types