MYL3

Across TCGA patient cohorts, MYL3 mutation is significantly associated with the RNA expression of many other genes, with 217 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL3-associated genes across cancer lineages are SETP22, SEPTIN7P4, and ZBED4. Each is linked with MYL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL3-to-partner and partner-to-MYL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SETP22 grouped by MYL3-low versus MYL3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL3→partner) and Y-score (partner→MYL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SETP22 →	+0.169	+3.363	.009	.008	3	2
UCEC	SEPTIN7P4 →	+0.113	+4.634	<.001	<.001	3	2
UCEC	ZBED4 →	+0.710	+3.343	.002	.005	3	2
UCEC	RAPGEF1 →	+0.648	+3.202	.002	.009	3	2
UCEC	NEK6 →	+0.863	+3.332	.001	.005	3	2
UCEC	SLC7A1 →	+0.974	+3.364	.002	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 217 associations by consensus.

SETP22 by MYL3 expression — UCEC

Explore this box plot interactively →