MYL3

Across TCGA cell cohorts, MYL3 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. CNS shows the largest number of these associations.

The most reproducible MYL3-associated genes across cancer lineages are OOSP2, KRTAP13-2, and SCGB1C1. Each is linked with MYL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL3-to-partner and partner-to-MYL3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OOSP2 grouped by MYL3-low versus MYL3-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL3→partner) and Y-score (partner→MYL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	OOSP2 →	+0.232	+5.321	<.001	.005	3	1
CNS	KRTAP13-2 →	+0.065	+4.981	<.001	.008	3	1
CNS	SCGB1C1 →	+0.336	+4.981	<.001	.008	3	1
CNS	CD300LD →	+0.042	+5.754	<.001	.002	3	1
CNS	OR2B3 →	+0.025	+5.321	<.001	.005	3	1
LARGE_INTESTINE	IL20 →	+0.216	+3.662	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

OOSP2 by MYL3 expression — CNS

Explore this box plot interactively →