MYL2

Across TCGA patient cohorts, MYL2 mutation is significantly associated with the RNA expression of many other genes, with 541 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL2-associated genes across cancer lineages are GNAQ, BTBD1, and WHAMM. Each is linked with MYL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL2-to-partner and partner-to-MYL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GNAQ grouped by MYL2-low versus MYL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL2→partner) and Y-score (partner→MYL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GNAQ →	+0.669	+2.354	<.001	.003	3	2
SKCM	BTBD1 →	+0.729	+3.350	.005	.005	3	2
UCEC	WHAMM →	+0.605	+2.354	<.001	.003	3	2
UCEC	ST7L →	+0.322	+2.756	.006	.003	3	2
UCEC	ZFAND6 →	+0.543	+3.354	.003	.005	3	2
LUSC	PYY3 →	+0.243	+5.321	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 541 associations by consensus.

GNAQ by MYL2 expression — UCEC

Explore this box plot interactively →