MYL2

Across TCGA patient cohorts, MYL2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL2-associated genes across cancer lineages are Notch1, ATM, and Caspase-7-cleavedD198. Each is linked with MYL2 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL2-to-partner and partner-to-MYL2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by MYL2-low versus MYL2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL2→partner) and Y-score (partner→MYL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.158	+3.331	.010	.005	3	2
UCEC	ATM →	-0.504	-3.156	.010	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.738	+3.169	.004	.018	3	2
UCEC	SLC1A5 →	-0.402	-2.693	.036	.006	3	1
UCEC	4E-BP1_pT37_T46 →	-0.411	-2.986	.012	.035	3	1
UCEC	Chk2_pT68 →	-0.164	-2.295	.043	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

Notch1 by MYL2 expression — UCEC

Explore this box plot interactively →