MYL12A

mutation — cross-omics
Cross-omicsMUTATION → IMMUNEPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, MYL12A mutation is significantly associated with the immune_cell of many other genes, with 2 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL12A-associated genes across cancer lineages are NK cells and CD8+ Tem. Each is linked with MYL12A in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL12A-to-partner and partner-to-MYL12A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NK cells grouped by MYL12A-low versus MYL12A-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL12A→partner) and Y-score (partner→MYL12A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
STADNK cells →+0.004+5.597.004.04031
UCECCD8+ Tem →+0.006+5.481<.001.02531
Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

NK cells by MYL12A expression — STAD

Box plot of NK cells in MYL12A-low vs MYL12A-high samples in STAD.

Explore this box plot interactively →

Exploration