MYL10

Across TCGA patient cohorts, MYL10 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL10-associated genes across cancer lineages are ATM, c-Met_pY1235, and INPP4B. Each is linked with MYL10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL10-to-partner and partner-to-MYL10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by MYL10-low versus MYL10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL10→partner) and Y-score (partner→MYL10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.725	-2.459	<.001	.020	3	2
UCEC	c-Met_pY1235 →	+0.074	+3.584	.039	.002	3	2
UCEC	INPP4B →	-0.397	-3.169	.011	.019	3	1
UCEC	JNK2 →	+0.218	+2.459	.023	.020	3	1
UCEC	Annexin-1 →	+0.516	+3.189	.042	.010	3	1
UCEC	STAT3_pY705 →	-0.501	-2.459	<.001	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

ATM by MYL10 expression — UCEC

Explore this box plot interactively →