MYL1

Across TCGA pan-cancer cohorts, MYL1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated MYL1 data layer compared with 16 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MYL1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated MYL1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where MYL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	II,III,IV	0.528	0.941	.004	32	view →
PDAC	OS	Tertile	All	0.806	0.548	.017	25	view →
LUAD	OS	Quartile	III,IV	0.557	1.000	.040	9	view →
HNSC	DFS	Median	III,IV	0.767	0.514	.008	8	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

MYL1–LSCC (OS)

Open the LSCC breakdown →