MYL1

Across TCGA patient cohorts, MYL1 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYL1-associated genes across cancer lineages are CD4+ Tcm, Endothelial cells, and mv Endothelial cells. Each is linked with MYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL1-to-partner and partner-to-MYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD4+ Tcm grouped by MYL1-low versus MYL1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL1→partner) and Y-score (partner→MYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CD4+ Tcm →	+0.015	+5.468	<.001	.043	3	1
UCEC	Endothelial cells →	-0.036	-2.991	.049	.036	3	1
UCEC	mv Endothelial cells →	-0.024	-3.169	.035	.019	3	1
UCEC	Th2 cells →	+0.206	+2.459	.017	.020	3	1
UCEC	Basophils →	+0.196	+2.459	.016	.020	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

CD4+ Tcm by MYL1 expression — HNSC

Explore this box plot interactively →