MYL1

Across TCGA cell cohorts, MYL1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MYL1-associated genes across cancer lineages are MINAR2, TTLL8, and DEFA4. Each is linked with MYL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYL1-to-partner and partner-to-MYL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MINAR2 grouped by MYL1-low versus MYL1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYL1→partner) and Y-score (partner→MYL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	MINAR2 →	+0.013	+4.977	<.001	.007	3	1
LARGE_INTESTINE	TTLL8 →	+0.005	+5.022	<.001	.002	3	1
LARGE_INTESTINE	DEFA4 →	+0.040	+5.022	<.001	.002	3	1
BLOOD_Leukemia	AMELX →	+0.023	+4.539	<.001	.007	3	1
BLOOD_Leukemia	OR2W1 →	+0.016	+4.539	<.001	.007	3	1
BLOOD_Leukemia	C3orf85 →	+0.036	+4.539	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

MINAR2 by MYL1 expression — SKIN

Explore this box plot interactively →