MYH8

Across TCGA patient cohorts, MYH8 mutation is significantly associated with the total protein of many other genes, with 73 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH8-associated genes across cancer lineages are ASNS, FoxM1, and YAP_pS127. Each is linked with MYH8 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYH8-to-partner and partner-to-MYH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MYH8-low versus MYH8-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH8→partner) and Y-score (partner→MYH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.405	+1.686	.003	.013	3	5
LUSC	FoxM1 →	+0.246	+1.298	.002	.014	3	5
COAD	YAP_pS127 →	-0.211	-2.584	.033	.010	3	5
UCEC	Cyclin-B1 →	+0.539	+1.469	<.001	<.001	3	4
STAD	p38-MAPK_pT180_Y182 →	-0.424	-2.000	.004	.030	3	4
UCEC	PCNA →	+0.229	+1.624	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 73 associations by consensus.

ASNS by MYH8 expression — COAD

Explore this box plot interactively →