MYH8

Across TCGA cell cohorts, MYH8 mutation is significantly associated with the RNA expression of many other genes, with 1,294 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH8-associated genes across cancer lineages are H1-1, PFAS, and SPATA45. Each is linked with MYH8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH8-to-partner and partner-to-MYH8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, H1-1 grouped by MYH8-low versus MYH8-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH8→partner) and Y-score (partner→MYH8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	H1-1 →	+0.197	+2.524	<.001	.003	3	3
SKIN	PFAS →	+0.601	+2.652	.002	.001	3	3
URINARY_TRACT	SPATA45 →	+0.111	+3.408	<.001	.004	3	2
BONE	TTLL10 →	+0.050	+5.169	<.001	.004	3	2
BONE	OR1M1 →	+0.013	+5.169	<.001	.004	3	2
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,294 associations by consensus.

H1-1 by MYH8 expression — LUNG_SCLC

Explore this box plot interactively →