MYH7

Across TCGA patient cohorts, MYH7 mutation is significantly associated with the total protein of many other genes, with 87 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH7-associated genes across cancer lineages are Cyclin-B1, PCNA, and eEF2. Each is linked with MYH7 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH7-to-partner and partner-to-MYH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by MYH7-low versus MYH7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH7→partner) and Y-score (partner→MYH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.468	+1.637	<.001	<.001	3	6
COAD	PCNA →	+0.203	+1.856	.013	.004	3	6
BLCA	eEF2 →	+0.268	+2.132	.006	.010	3	5
BLCA	EGFR_pY1068 →	-0.383	-3.169	.033	.017	3	5
COAD	Caspase-7-cleavedD198 →	+1.102	+2.745	<.001	<.001	3	5
LUAD	4E-BP1 →	+0.279	+2.700	.007	.005	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 87 associations by consensus.

Cyclin-B1 by MYH7 expression — UCEC

Explore this box plot interactively →