MYH7

Across TCGA cell cohorts, MYH7 mutation is significantly associated with the RNA expression of many other genes, with 665 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH7-associated genes across cancer lineages are EYA3, TRIM62, and RPF1. Each is linked with MYH7 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH7-to-partner and partner-to-MYH7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EYA3 grouped by MYH7-low versus MYH7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH7→partner) and Y-score (partner→MYH7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	EYA3 →	+0.572	+3.584	<.001	<.001	3	3
LARGE_INTESTINE	TRIM62 →	+0.487	+2.584	.001	.002	3	3
LARGE_INTESTINE	RPF1 →	+0.640	+2.936	<.001	<.001	3	3
PANCREAS	ADH1A →	+0.483	+3.222	.003	.006	3	2
LUNG_SCLC	DCSTAMP →	+0.210	+2.428	.004	.007	3	2
SOFT_TISSUE	GSTM5 →	+0.297	+3.781	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 665 associations by consensus.

EYA3 by MYH7 expression — LARGE_INTESTINE

Explore this box plot interactively →