Across TCGA patient cohorts, MYH6 mutation is significantly associated with the total protein of many other genes, with 92 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH6-associated genes across cancer lineages are Caspase-7-cleavedD198, PCNA, and TFRC. Each is linked with MYH6 in more than 5 cancer types. Because this analysis shows association rather than direction, both MYH6-to-partner and partner-to-MYH6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH6→partner) and Y-score (partner→MYH6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.613	+1.550	<.001	.002	3	6
STAD	PCNA →	+0.285	+1.999	.005	.009	3	5
LUAD	TFRC →	+0.703	+3.459	<.001	.004	3	4
COAD	ASNS →	+0.391	+2.000	.001	.027	3	4
UCEC	Cyclin-B1 →	+0.547	+2.807	<.001	<.001	3	4
STAD	eEF2 →	+0.222	+2.321	.038	.032	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

Exploration

MYH6 survival (RNA) · tumor vs normal (RNA) · all MYH6 data types