MYH3

Across TCGA patient cohorts, MYH3 mutation is significantly associated with the total protein of many other genes, with 105 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH3-associated genes across cancer lineages are PCNA, FASN, and TIGAR. Each is linked with MYH3 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYH3-to-partner and partner-to-MYH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by MYH3-low versus MYH3-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH3→partner) and Y-score (partner→MYH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	PCNA →	+0.219	+3.017	.008	.017	3	4
LUAD	FASN →	+0.348	+3.169	.048	.018	3	4
LUSC	TIGAR →	+0.177	+1.746	<.001	.024	3	4
STAD	FoxM1 →	+0.454	+2.490	<.001	.009	3	4
COAD	INPP4B →	-0.284	-1.807	.021	.024	3	4
UCEC	PDCD4 →	-0.532	-1.624	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 105 associations by consensus.

PCNA by MYH3 expression — BLCA

Explore this box plot interactively →