MYH3

Across TCGA cell cohorts, MYH3 mutation is significantly associated with the RNA expression of many other genes, with 342 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH3-associated genes across cancer lineages are TRIM37, DTWD2, and QRFP. Each is linked with MYH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYH3-to-partner and partner-to-MYH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM37 grouped by MYH3-low versus MYH3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH3→partner) and Y-score (partner→MYH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRIM37 →	+0.686	+3.364	.001	.002	3	2
SKIN	DTWD2 →	+0.484	+3.169	.009	.009	3	2
SKIN	QRFP →	+0.247	+2.628	.007	.002	3	2
BREAST	OR10K2 →	+0.047	+4.781	<.001	.003	3	2
BREAST	OR10T2 →	+0.137	+4.781	<.001	.003	3	2
LARGE_INTESTINE	L3MBTL2 →	+0.540	+3.364	.008	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 342 associations by consensus.

TRIM37 by MYH3 expression — LARGE_INTESTINE

Explore this box plot interactively →