MYH2

Across TCGA patient cohorts, MYH2 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH2-associated genes across cancer lineages are MSH2, 4E-BP1, and PCNA. Each is linked with MYH2 in more than 3 cancer types. Because this analysis shows association rather than direction, both MYH2-to-partner and partner-to-MYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by MYH2-low versus MYH2-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH2→partner) and Y-score (partner→MYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	MSH2 →	+0.269	+1.675	<.001	.005	3	4
UCEC	4E-BP1 →	+0.280	+1.544	<.001	<.001	3	4
STAD	PCNA →	+0.197	+3.584	.049	.002	3	4
STAD	Mre11 →	-0.113	-2.584	.001	.008	3	4
COAD	Caspase-7-cleavedD198 →	+0.919	+2.016	<.001	.015	3	4
LUAD	ER-alpha →	-0.170	-1.807	.021	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

MSH2 by MYH2 expression — LUAD

Explore this box plot interactively →