MYH2

Across TCGA cell cohorts, MYH2 mutation is significantly associated with the RNA expression of many other genes, with 987 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH2-associated genes across cancer lineages are STK25, C1orf146, and HSPB2. Each is linked with MYH2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH2-to-partner and partner-to-MYH2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STK25 grouped by MYH2-low versus MYH2-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH2→partner) and Y-score (partner→MYH2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	STK25 →	+0.589	+2.743	.005	.001	3	3
SKIN	C1orf146 →	+0.021	+2.099	<.001	.004	3	3
BLOOD_Leukemia	HSPB2 →	+0.312	+4.141	<.001	<.001	3	3
LARGE_INTESTINE	IRF2BP1 →	+0.668	+3.389	.002	.001	3	3
SOFT_TISSUE	OR9A4 →	+0.029	+5.369	<.001	.004	3	2
OESOPHAGUS	OCSTAMP →	+0.008	+2.857	.004	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 987 associations by consensus.

STK25 by MYH2 expression — SKIN

Explore this box plot interactively →