MYH16

Across TCGA patient cohorts, MYH16 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH16-associated genes across cancer lineages are 14-3-3_beta, ERK2, and Ku80. Each is linked with MYH16 in more than 1 cancer types. Because this analysis shows association rather than direction, both MYH16-to-partner and partner-to-MYH16 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MYH16-low versus MYH16-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH16→partner) and Y-score (partner→MYH16) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.136	-3.143	.003	.018	3	1
UCEC	ERK2 →	+0.297	+3.321	<.001	.010	3	1
UCEC	Ku80 →	+0.296	+2.598	.007	.006	3	1
UCEC	Notch1 →	+0.135	+2.584	.039	.011	3	1
UCEC	p70-S6K_pT389 →	-0.185	-2.312	.037	.034	3	1
UCEC	PARP_cleaved →	-0.313	-3.321	.029	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by MYH16 expression — UCEC

Explore this box plot interactively →