MYH15

Across TCGA patient cohorts, MYH15 mutation is significantly associated with the RNA expression of many other genes, with 7,268 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MYH15-associated genes across cancer lineages are UBE2G1, PSMB7, and INCENP. Each is linked with MYH15 in more than 4 cancer types. Because this analysis shows association rather than direction, both MYH15-to-partner and partner-to-MYH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2G1 grouped by MYH15-low versus MYH15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH15→partner) and Y-score (partner→MYH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UBE2G1 →	+0.465	+1.488	<.001	<.001	3	5
UCEC	PSMB7 →	+0.354	+1.531	<.001	<.001	3	5
UCEC	INCENP →	+0.465	+2.169	.001	<.001	3	5
UCEC	MLF2 →	+0.229	+2.403	.004	<.001	3	5
CESC	PPP6R1 →	+0.436	+3.336	.008	.004	3	4
COAD	PSMD9 →	+0.415	+2.512	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,268 associations by consensus.

UBE2G1 by MYH15 expression — UCEC

Explore this box plot interactively →