MYH15

Across TCGA cell cohorts, MYH15 mutation is significantly associated with the RNA expression of many other genes, with 529 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible MYH15-associated genes across cancer lineages are DESI1, CLUAP1, and MRPL19. Each is linked with MYH15 in more than 2 cancer types. Because this analysis shows association rather than direction, both MYH15-to-partner and partner-to-MYH15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DESI1 grouped by MYH15-low versus MYH15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MYH15→partner) and Y-score (partner→MYH15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DESI1 →	+0.415	+3.321	.002	.003	2	3
LARGE_INTESTINE	CLUAP1 →	+0.517	+3.252	.003	.002	3	2
LARGE_INTESTINE	MRPL19 →	+0.486	+1.949	.002	.002	3	2
LARGE_INTESTINE	NEIL2 →	+0.559	+3.087	.008	.006	3	2
LARGE_INTESTINE	OTUD3 →	+0.670	+3.169	.003	.009	3	2
LARGE_INTESTINE	MRM3 →	+0.590	+3.321	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 529 associations by consensus.

DESI1 by MYH15 expression — LARGE_INTESTINE

Explore this box plot interactively →